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《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:

期数:

2020年03期

页码:

324-328

栏目:

论著

出版日期:

2020-06-20

文章信息/Info

Title:

Clinical value of interferon γ release assay in diagnosis of active pulmonary tuberculosis

作者:

瓦热斯江·衣不拉音¹; 吴振华¹; 孙 伟¹; 阿布力米提·阿布来提²

830011 乌鲁木齐,新疆医科大学第三临床医学院胸外科¹ 830011 乌鲁木齐,新疆医科大学附属肿瘤医院胸外科²

Author(s):

Huang Dedong¹;  Liu Tinggui²;  Zhang Yun²;  Shi Jie¹;  Han Tiantian¹;  Zhuang Jianwen¹;  Wei Xifei¹;  Gu Xing³.

¹Department of Infectious Diseases, 903rd Hospital of PLA, Hangzhou 310013, China; ²Department of Infectious Diseases, Zhijin County People's Hospital, Zhijin 552100, Guizhou Province, China; ³Department of Respiratory and Critical Care Medicine, Tangdu Hospital, Air Force Military Medical University, Xi'an 710038, China

关键词:

肺腺癌;  IGF1R;  Cezanne-1;  EGFR基因突变;  相关性;  预测价

Keywords:

Tuberculosis interferonγ release assay;  Tuberculin skin test;  Tuberculosis antibody

分类号:

R563,R734.2

DOI:

10.3877/cma.j.issn.1674-6902.2020.03.007

摘要:

目的 在我国西南部结核病高发区,评价结核γ-干扰素释放试验(tuberculosis interferonγ release assay, TB-IGRA)在疑似肺结核中诊断活动性肺结核的价值。方法 纳入2018年12月20日至2019年12月20日在贵州省织金县人民医院诊断的疑似肺结核患者1 627名,用TB-IGRA、结核菌素皮肤实验(TST)、结核分枝杆菌抗体(TBAb)或结核分枝杆菌免疫球蛋白(TB-Ig)检测诊断活动性肺结核,比较其敏感性、特异性、准确性。并分析卡介苗(Bacillus Calmette-Guérin, BCG)接种对结果的影响。结果 TB-IGRA的敏感性、特异性和准确性,依次为:91.26%、80.13%和89.37%,均高于TST、TB-IgG的检测。TB-IGRA 诊断疑似肺结核中的活动性肺结核,不受BCG接种的影响(χ²=0.05,P=0.83)。BCG接种对TST诊断疑似肺结核中的活动性肺结核影响明显(χ²=108.17,P<0.001)。结论 TB-IGRA在我国西南部结核病高发区诊断活动性肺结核有很高的敏感性、特异性,较TST、TB-Ig有更高价值,且不受BCG接种的影响。

Abstract:

Objective To evaluate the clinical value of tuberculosis interferon γ release assay(TB-IGRA)in the diagnosis of active pulmonary tuberculosis among the suspected pulmonary tuberculosis patients in the southwest region of China with high TB burden. Methods A total of 1627 suspected pulmonary tuberculosis patients from the Department of Infectious Diseases of Zhijin County People's Hospital in Guizhou Province in China between December 20, 2018 and December 20, 2019 were enrolled for this study. Then TB-IGRA, tuberculin skin test(TST)and tuberculosis immunoglobulin(TB-Ig)were used respectively to diagnose the active pulmonary tuberculosis. And the sensitivity, specificity and accuracy were compared among the patients with TB-IGRA, TST, and TB-Ig, respectively. The influences of Bacillus Calmette-Guérin(BCG)vaccination on these tests were analyzed. Results The sensitivity, specificity and accuracy of TB-IGRA were 91.26%, 80.13%, and 89.37%, respectively, and they were higher than those of TST or TB-IgG. The results of TB-IGRA diagnosis for active pulmonary tuberculosis among the suspected pulmonary tuberculosis patients were not affected by BCG vaccination(χ²=0.05, P=0.83). However, BCG vaccination affected the results of TST significantly(χ²=108.17, P<0.001). Conclusion TB-IGRA seems to be superior to TST or TB-IgG as a diagnostic tool for the detection of active pulmonary tuberculosis among the suspected pulmonary tuberculosis patients in southwest region of China with high TB burden and it is not affected by BCG vaccination.

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备注/Memo

备注/Memo:

基金项目: 新疆维吾尔自治区自然科学基金资助项目(2017D01C398)

常用功能

更新日期/Last Update: 2020-06-20