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《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:

期数:

2020年03期

页码:

340-344

栏目:

论著

出版日期:

2020-06-20

文章信息/Info

Title:

Effects of Shufeng Jiedu capsules on acute upper respiratory tract infection in elderly patients

作者:

赖志远; 刘振玉; 李修江; 周强平

330006 江西,南昌大学第一附属医院急诊创伤抢救中心

Author(s):

Chen Xiaoxia¹;  Li Wangping¹;  Ma Lijie²;  Jin Faguang¹;  Pan Lei¹;  Xue Yunli³;  Li Xiangyu⁴.

¹Department of Respiratory and Critical Care Medicine, Tangdu Hospital, Air Force Military Medical University, Xi'an 710038, China; ²Department of Respiratory and Critical Care Medicine, General Hospital of Western Theater Command, Chengdu 610083, China; ³Beijing Yuanbo Kanghui Medical Information Consulting Co. Ltd, Beijing 100071, China; ⁴Anhui Jiren Pharmaceutical Co.Ltd, Bozhou 236800, Anhui Province, China

关键词:

急性肺损伤;  Nix;  机械牵张;  胸部撞击伤

Keywords:

Shufeng Jiedu capsules;  Elderly;  Upper respiratory tract infection;  Prospective study

分类号:

R563

DOI:

10.3877/cma.j.issn.1674-6902.2020.03.010

摘要:

目的 研究疏风解毒胶囊治疗老年急性上呼吸道感染的临床效果。方法 于2010年5月至2012年4月4所研究中心按照入排标准共纳入120例患者,对诊断明确的上感患者服用疏风解毒胶囊治疗4粒,3/日,连服3天,记录治疗前、治疗中、治疗后生命体征及发热、咽痛、头胀痛、鼻塞、流浊涕、咳嗽、咽黏膜充血等症状变化。分别对疾病疗效、体温疗效及单项症状疗效(分为痊愈、显效、有效、无效)行统计学分析,并进行量化评分,评价其安全性。结果 最终完成试验114例,其中男性54例,女性60例; 疗效分析示总有效率94.7%(108/114),治疗3天后93.8%(107/114)患者体温恢复正常,中位体温起效时间为4.0 h。单项症状观察指标变化结果显示,咽痛、咳嗽、头胀痛、鼻塞、流浊涕和咽黏膜充血治疗总有效率(例)分别为:82.4%(94/114)、82.4%(94/114)、81.6%(93/114)、79.2%(89/114)、79.2%(89/114)和79.2%(89/114)。进一步量化分析后显示对发热、咽痛缓解明显,咳嗽、头胀痛、鼻塞、流浊涕和咽黏膜充血也有较好的缓解效果。对体温、呼吸频率、舒张压亦有改善。结论 疏风解毒胶囊对于老年急性上呼吸道感染有显著的治疗效果,可作为老年急性上呼吸道感染的选择。

Abstract:

Objective To study the clinical effects of Shufeng Jiedu capsules in treating elderly patients with acute upper respiratory tract infection. Methods From May 2010 to April 2012, four research centers enrolled 120 patients according to the admission criteria. For the patients with a clear diagnosis of acute upper respiratory tract infection, Shufeng Jiedu capsules were used, 4 capsules each time, 3 times every day, for 3 days. The vital signs and the symptoms such as fever, sore throat, head pain, nasal obstruction, turbid nasal discharge, cough, and pharyngeal mucosal hyperemia, were recorded before, during, and after treatment, respectively. Statistical analyses were performed on the efficacies of Shufeng Jiedu capsules on the disease, the body temperature, and other individual symptoms(including healing, marked effect, effectiveness, and ineffectiveness), and quantitative scoring was performed to evaluate its safety. Results A total of 114 patients(54 males and 60 females)completed this trial. The efficacy analysis showed a total effective rate of 94.7%(108/114). After 3 days of treatment, the body temperature of 93.8%(107/114)of the patients returned to the normal range, and the median time for the body temperature becoming effective was 4.0 hours. The results of changes in individual symptoms showed that the total effective rates of treatment for sore throat, cough, head pain, nasal obstruction, turbid nasal discharge, cough, and pharyngeal mucosal hyperemia were 82.4%(94/114), 82.4%(94/114), 81.6%(93/114), 79.2%(89/114), 79.2%(89/114), and 79.2%(89/114), respectively. Further quantitative analysis showed that fever and pharyngeal pain relief were obvious. Better effects were also found in cough, head pain, nasal obstruction and pharyngeal mucosal congestion. Shufeng Jiedu capsules also improved the body temperature, respiratory rate, and diastolic blood pressure. Conclusion Shufeng Jiedu capsules have significant therapeutic effects on the elderly patients with acute upper respiratory tract infection, and therefore, can be used as an option for elderly patients with acute upper respiratory tract infection.

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备注/Memo

备注/Memo:

基金项目: 江西省教育厅课题(170044)

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更新日期/Last Update: 2020-06-20