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[1]魏胜全,薛 华,薛慧君.糠酸氟替卡松/维兰特罗对慢性阻塞性肺疾病急性发作期的影响[J].中华肺部疾病杂志,2020,(05):602-606.[doi:10.3877/cma.j.issn.1674-6902.2020.05.005]
　Wei Shengquan,Xue Hua,Xue Huijun..Effects of fluticasone furoate/vilantrol on on lung function, peripheral blood Th1/Th2 drift, GSH-PX, MDA and 8-OHdG levels in patients with acute exacerbation of COPD[J].,2020,(05):602-606.[doi:10.3877/cma.j.issn.1674-6902.2020.05.005]
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糠酸氟替卡松/维兰特罗对慢性阻塞性肺疾病急性发作期的影响(PDF)

《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2020年05期
页码:
602-606
栏目:
论著
出版日期:
2020-10-20

文章信息/Info

Title:
Effects of fluticasone furoate/vilantrol on on lung function, peripheral blood Th1/Th2 drift, GSH-PX, MDA and 8-OHdG levels in patients with acute exacerbation of COPD
作者:
魏胜全1; 薛 华2; 薛慧君3
721000 陕西省宝鸡市人民医院呼吸科1 712003 咸阳市第一人民医院呼吸科2 518067 深圳大学总医院呼吸科3
Author(s):
Wei Shengquan1;  Xue Hua2;  Xue Huijun3.
1Department of Respiration, Baoji People's Hospital of Shaanxi Province, Baoji 721000, China; 2Department of Respiration, Xianyang First People's Hospital, Xianyang 712000, China; 3Department of Respiration; Shenzhen University General Hospital,Shenzhen 518067, China
关键词:
糠酸氟替卡松/维兰特罗;  肺疾病; 慢性阻塞性;  急性发作期;  肺功能;  Th1/Th2
Keywords:
Fluticasone furoate/vilantrol;  Chronic obstructive pulmonary disease;  Acute exacerbation;  Lung function;  Th1/Th2
分类号:
R563
DOI:
10.3877/cma.j.issn.1674-6902.2020.05.005
摘要:
目的 观察糠酸氟替卡松/维兰特罗(FF/VI)对慢性阻塞性肺病(COPD)急性发作期患者肺功能、外周血Th1/Th2漂移、谷胱甘肽过氧化物酶(GSH-PX)、丙二醛(MDA)和8-羟基脱氧鸟苷(8-OHdG)水平的影响。方法 选取本院100例COPD急性发作期患者,以数字表法随机分为2组,对照组予以常规治疗,研究组于其基础上使用FF/VI,比较2组治疗前后肺功能指标[残气量与肺总量百分比(RV/TLC%)、1 s末用力呼气容积占预计值百分比(FEV1%)]、GSH-PX、MDA、8-OhdG水平及不良反应情况; 并取同期50例体检健康者纳入健康组,分析研究组与对照组外周血Th1/Th2漂移[干扰素γ(INF-γ)、白介素4(IL-4)及IL-4/INF-γ]情况。结果 研究组治疗后FEV1%明显高于对照组(P<0.05),且RV/TLC%明显低于对照组(P<0.05); 2组治疗前INF-γ、IL-4均显著高于健康组(P<0.05),INF-γ/IL-4显著低于健康组(P<0.05),2组治疗后INF-γ、IL-4显著降低(P<0.05),且INF-γ/IL-4显著升高(P<0.05),研究组INF-γ、IL-4明显低于对照组(P<0.05),INF-γ/IL-4明显高于对照组(P<0.05); 研究组治疗后GSH-PX水平明显高于对照组(P<0.05),MDA、8-OhdG水平明显低于对照组(P<0.05); 2组不良反应总发生率比较无显著差异(P>0.05)。结论 FF/VI可有效调节COPD急性发作期患者外周血Th1/Th2漂移,改善GSH-PX、MDA、8-OhdG表达水平,增强机体免疫能力与抗氧化功能,促进肺功能恢复。
Abstract:
Objective To observe the effects of fluticasone furoate/vilantrol(FF/VI)on lung function, peripheral blood Th1/Th2 drift, glutathione peroxidase(GSH-PX), malondialdehyde(MDA)and 8-hydroxy-2'-deoxyguanosine(8-OHdG)levels in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD). Methods A total of 100 patients with acute exacerbation of COPD were selected from the hospital and randomly divided into two groups by number table method. The control group were given conventional treatment. On the basis, the experimental group were additionally treated with FF/VI. Lung function indexes [the ratio of residual volume to total lung capacity(RV/TLC%), the percentage of forced expiratory volume in one second in the predicted value(FEV1%)], levels of GSH-PX, MDA and 8-OhdG and adverse reactions were compared between the two groups before and after treatment. 50 healthy people were selected and included in the health group at the same time. The situation of peripheral blood Th1/Th2 drift [interferon γ(INF-γ), interleukin 4(IL-4)and IL-4/INF-γ] in the experimental group and the control group was analyzed. Results After treatment, the FEV1% in the experimental group was significantly higher than that in the control group(P<0.05), and the RV/TLC% was significantly lower than that in the control group(P<0.05). Before treatment, INF-γ and IL-4 were significantly higher in the experimental group and the control group than in the healthy group(P<0.05), while INF-γ/IL-4 was significantly lower than the healthy group(P<0.05). After treatment, INF-γ and IL-4 in the experimental group and the control group decreased significantly(P<0.05), and INF-γ/IL-4 increased significantly(P<0.05). INF-γ and IL-4 in the experimental group were significantly lower than those in the control group(P<0.05), and INF-γ/IL-4 was significantly higher than the control group(P<0.05). After treatment, the GSH-PX level in the experimental group was significantly higher than that in the control group(P<0.05), and the levels of MDA and 8-OhdG were significantly lower than the control group(P<0.05). There was no significant difference in the overall incidence of adverse reactions between the two groups(P>0.05). Conclusion FF/VI can effectively regulate the peripheral blood Th1/Th2 drift in patients with acute exacerbation of COPD, improve the expression levels of GSH-PX, MDA and 8-OhdG, and enhance the immune capacity, with antioxidant effect. It also can promote the recovery of lung function.

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备注/Memo

备注/Memo:
基金项目: 国家青年科学基金资助项目(81682253) 通信作者: 魏胜全, Email: 15249178003@139.com
更新日期/Last Update: 2020-10-20