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《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:

期数:

2021年04期

页码:

412-416

栏目:

论著

出版日期:

2021-08-20

文章信息/Info

Title:

Nip-like protein Xis overexpressed and predicts poor prognosis in non-small cell lung cancer

作者:

陈 燏¹; 王玉秀²; 闵凌峰²

214500 靖江,江苏省靖江人民医院¹ 225001 扬州,江苏省苏北人民医院·大连医科大学第二临床学院·扬州大学临床医学院²

Author(s):

Chen Yu¹;  Wang Yuxiu²;  Min Lingfeng².

¹Department of Respiratory Medicine, Jingjiang People's Hospital, Yangzhou University, Jingjiang 214500, China; ²Department of Respiratory of Subei People's Hospital, The Second Clinical Medical College of Dalian Medical University, Clinical Medical College of Yangzhou University, Yangzhou, 225001, China

关键词:

Nip样蛋白;  非小细胞肺癌;  临床特征;  预后

Keywords:

Nip-like protein X;  Non-small cell lung cancer;  Clinicopathologic characteristics;  Prognosis

分类号:

R734.2

DOI:

10.3877/cma.j.issn.1674-6902.2021.04.002

摘要:

目的 探讨Nip样蛋白(Nip-like protein X,NIX/BNIP3L)在非小细胞肺癌(non-small cell lung cancer, NSCLC)中的表达情况及其临床特征和预后中的影响。方法 选择在江苏省靖江市人民医院就诊首次确诊为NSCLC并行手术治疗的68例患者的癌组织、癌旁组织及其临床特征信息,用免疫组化法检测癌组织以及癌旁组织NIX表达情况,分析NIX表达情况与患者临床病理特征之间的相关性及对其预后的影响。结果 免疫组化结果显示NIX在NSCLC组织表达较癌旁组织明显上调,并且NIX表达差异与NSCLC患者分化程度、淋巴结转移程度存在明显的相关性(P=0.001,P=0.005),而与患者性别、年龄、病理类型、远处转移、TNM分期无明显的相关性。多因素Cox回归分析显示NIX蛋白表达、区域淋巴结转移、病理分化程度、吸烟状况可作为非小细胞肺癌患者的独立预后因子。基于NIX在NACLC表达差异,K-M分析结果显示NIX表达的上调与患者总体生存率以及无进展生存率的下降存在明显的相关性(P<0.01)。结论 NIX在NSCLC中的表达明显上调,NIX的表达上调可能与NSCLC的侵袭转移存在一定的相关性,NIX的表达上调可影响NSCKLC患者的预后,NIX有望成为NSCLC的治疗一新靶点。

Abstract:

Objective To investigate the expression and clinical significance of Nip-like protein X(NIX/BNIP3L)in non-small cell lung cancer(NSCLC). Methods It was collected that tumor and adjacent tissue samples from 68 patients with NSCLC, and conducted immunohistochemistry to detect NIX expression. The correlations between NIX expression and clinicopathologic characteristics and prognosis were evaluated using the SPSS 22.0 software package. Results NIX was highly expressed in NSCLC tissue samples. NIX expression was correlated with the degree of NSCLC differentiation and lymph node metastasis(P=0.001, P=0.005), but not with sex, age, pathologic type, distant metastasis, or TNM stage. In addition, multivariate Cox regression analysis showed that NIX protein expression, regional lymph node metastasis, pathological differentiation, and smoking status were independent prognostic factors for NSCLC patients.Based on the differences of NIX expression in NACLC, TheK-M analysis results showed that the upregulation of NIX expression was significantly correlated with the decrease of overall survival rate and progression-free survival rateinNSCLC(P<0.01). Conclusion NIX expression is elevated in NSCLC and may contribute to the invasion and metastasis of lung cancer. Upregulation of NIX expression can affect the prognosis of NSCLC patients.NIX may represent a therapeutic target for the treatment of NSCLC.

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备注/Memo

备注/Memo:

基金项目: 国家自然科学基金资助项目(81870033); 江苏省“六大人才高峰计划”(2015-WSN-106)江苏省医学科学研究基金(QNRC2016340); 扬州市“十三五”高层次人才科研基金(ZDRC201866)
通信作者: 闵凌峰, Email: minlingfeng@126.com

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更新日期/Last Update: 2021-08-20