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[1]雷 娇,倪丹红.孟鲁司特钠对儿童哮喘急性发作期的疗效及气道功能的影响[J].中华肺部疾病杂志,2021,(05):611-613.[doi:10.3877/cma.j.issn.1674-6902.2021.05.016]
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孟鲁司特钠对儿童哮喘急性发作期的疗效及气道功能的影响(PDF)

《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2021年05期
页码:
611-613
栏目:
临床研究
出版日期:
2021-10-20

文章信息/Info

Title:
-
作者:
雷 娇1; 倪丹红2
810000 西宁,青海大学附属医院临床药学科1 710082 陕西,西安市第五医院药剂科2
Author(s):
-
关键词:
孟鲁司特钠;  长效β2受体激动剂;  哮喘急性发作期;  气道功能
Keywords:
-
分类号:
R562
DOI:
10.3877/cma.j.issn.1674-6902.2021.05.016
摘要:
目的 分析孟鲁司特钠联合长效β2受体激动剂治疗哮喘急性发作期的临床疗效及对气道功能的影响。方法 选取我院2019年8月至2021 年6月接诊的87例支气管哮喘急性发作患儿作为对象,随机分为观察组和对照组,对照组43例给予单一长效β2受体激动剂治疗,观察组44例在对照组基础上联合孟鲁司特钠咀嚼片治疗,两组患儿均于治疗1周后评估临床疗效,比较两组患儿治疗前后炎症因子水平[血清嗜酸性粒细胞(EOS)计数、嗜酸性粒细胞阳离子蛋白(ECP)及白细胞介素-4(IL-4)]、气道功能指标[用力肺活量(FVC)、第1 s用力呼气容积(FEV1)及最大呼气峰流速(PEF)]及治疗期间不良反应发生情况。结果 观察组治疗有效率(95.45%)高于对照组(81.39%),(P<0.05); 治疗后,两组患儿的ECP、IL-4及EOS水平较治疗前均降低,且观察组均低于对照组,(P<0.05); 治疗后,两组患儿的PEF及FEV1/FVC水平均高于治疗前,且观察组均高于对照组,差异具有统计学意义(P<0.05); 两组患儿不良反应发生率比较差异无统计学意义(P>0.05)。结论 给予支气管哮喘患儿孟鲁司特钠联合长效β2受体激动剂治疗,有效提高患儿的临床治疗效果,改善气道功能,降低炎症因子水平。
Abstract:
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备注/Memo

备注/Memo:
基金项目: 青海大学中青年科研基金项目(2019-QYY-6)
通信作者: 倪丹红, Email: ndh714906@163.com
更新日期/Last Update: 2021-10-20