|本期目录/Table of Contents|

[1]朱成华,蔡璐,安伯萍,等.慢性阻塞性肺疾病伴认知功能障碍患者血清lipocalin-2表达及意义[J].中华肺部疾病杂志,2022,(01):29-32.[doi:10.3877/cma.j.issn.1674-6902.2022.01.007]
　Zhu Chenghua,Cai Lu,An Boping,et al.Expression and Significance of Serum lipocalin-2 in Patients with chronic obstructive pulmonary disease with Cognitive Impairment[J].,2022,(01):29-32.[doi:10.3877/cma.j.issn.1674-6902.2022.01.007]
点击复制

慢性阻塞性肺疾病伴认知功能障碍患者血清lipocalin-2表达及意义(PDF)

《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2022年01期
页码:
29-32
栏目:
论著
出版日期:
2022-02-20

文章信息/Info

Title:
Expression and Significance of Serum lipocalin-2 in Patients with chronic obstructive pulmonary disease with Cognitive Impairment
作者:
朱成华1; 蔡璐2; 安伯萍1; 杜强1
210011 江苏,南京医科大学第二附属医院呼吸科1、内分泌科2
Author(s):
Zhu Chenghua1;  Cai Lu2;  An Boping1;  Du Qiang1.
1Department of Respiratory Medicine, the second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China; 2Department of Endocrinology Medicine, the Second Affiliated Hospital of Nanjing Medical university, Nanjing, 210011, China
关键词:
肺疾病; 慢性阻塞性;  认知功能;  蒙特利尔认知评估量表;  脂质运载蛋白-2
Keywords:
Chronic obstructive pulmonary disease;  Cognitive function;  Montreal cognitive assessment;  lipocalin-2
分类号:
R563
DOI:
10.3877/cma.j.issn.1674-6902.2022.01.007
摘要:
目的 分析血清脂质运载蛋白-2(lipocalin-2)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)稳定期伴认知障碍患者血清中的表达变化及其意义。方法 依据蒙特利尔认知评估量表(Montreal cognitive assessment, MoCA)评分,MoCA分值<26分者为认知受损,将43例COPD稳定期的患者分为认知障碍组23例及认知正常组20例,并选取20例健康体检者做对照组; 采用酶联免疫吸附实验(ELISA)分别检测患者外周静脉血清脂质运载蛋白-2(lipocalin-2)水平; 分析血清脂质运载蛋白-2与认知功能的相关性,根据血清lipocalin-2水平预测认知障碍的受试者工作特征(ROC)曲线。结果 与健康对照组相比(60.37±10.77)μg/ml,COPD稳定期伴认知障碍患者血清lipocalin-2水平(82.76±12.90)μg/ml显著增加(P<0.05); 与COPD稳定期认知正常组(69.70±11.51)μg/ml相比,认知功能障碍组血清lipocalin-2水平显著升高,差别有统计学意义(P<0.05)。Pearson相关分析结果显示血清lipocalin-2水平与MoCA评分呈负相关(r=-0.749,P<0.001); 血清lipocalin-2水平预测COPD稳定期患者认知功能障碍的ROC曲线下面积分别为0.804(95%CI 0.664～0.945,P<0.001)。结论 血清lipocalin-2表达水平与COPD稳定期患者认知功能障碍密切相关。血清lipocalin-2 水平检测可能成为COPD患者出现认知功能障碍的一个重要诊断指标。
Abstract:
Objective To investigate the correlation and clinical significance of serum lipocalin-2 level with cognitive impairment in patients with the stable stage of chronic obstructive pulmonary disease(COPD). Methods According to the Montreal cognitive assessment(MoCA)scale standard for evaluation,a cutoff score of <26 defined as mild cognitive impairment(MCI).A total of 43 patients in the stable stage of COPD were divided into a cognitive impairment group(Cog I)(23 patients)and a cognitive normal group(Cog N)(20 patients), and 20 healthy Subjects as control group. The level of serum lipocalin-2 in each group was detected by enzyme-linked immunosorbent assay(ELISA), the correlation between lipocalin-2 and cognitive function was analyzed, and the ROC curve of cognitive impairment was predicted according to the level of lipocalin-2. Results Compared with the healthy control group(60.37±10.77)μg/ml, the serum level of lipocalin-2 in stable COPD patients with cognitive impairment(82.76±12.90)μg/ml was significant higher(P<0.05). Compared with than the cognitive normal group(69.70±11.51)μg/ml, the protein level of lipocalin-2 was increased in serum of stable COPD patients with cognitive impairment(P<0.05). Pearson line correlation revealed that the serum level of lipocalin-2 was negatively correlated with MoCA score(r=-0.749, P<0.001), The areas under ROC curve of serum lipocalin-2 level to predict cognitive dysfunction in the COPD patients was 0.804(95%CI 0.664-0.945, P<0.001). Conclusion The serum lipocalin-2 level is closely related to the cognitive dysfunction of stable COPD patients. The detection of serum lipocalin-2 level may be an important diagnostic index of cognitive dysfunction in COPD patients.

参考文献/References:

1 任成山, 王关嵩, 钱桂生. 慢性阻塞性肺疾病的成因及其治疗的困惑与希望[J/CD]. 中华肺部疾病杂志(电子版), 2019, 12(2): 127-141.
2 Wang Y, Jia M, Yan X, et al. Increased neutrophil gelatinase-associated lipocalin(NGAL)promotes airway remodelling in chronic obstructive pulmonary disease[J]. Clin Sci(Lond), 2017, 131(11): 1147-1159.
3 Ferreira AC, Da Mesquita S, Sousa JC, et al. From the periphery to the brain: lipocalin-2, a friend or foe?[J]. Prog Neurobiol, 2015, 131: 120-136.
4 Pinyopornpanish K, Chattipakorn N, Chattipakorn SC. Lipocalin-2: Its perspectives in brain pathology and possible roles in cognition[J]. J Neuroendocrinol, 2019, 31(10): e12779.
5 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南[J]. 中华结核和呼吸杂志, 2013, 36(4): 255-264.
6 Huang Kewu, Yang Ting, Xu Jianying, et al. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study[J]. Lancet, 2019, 394: 407-418.
7 Villeneuve S, Pepin V, Rahayel S, et al. Mild cognitive impairment in moderate to severe COPD: a preliminary study[J]. Chest, 2012, 142(6): 1516-1523.
8 Kakkera Krishna, Padala Kalpana P, Kodali Maneetha, et al. Association of chronic obstructive pulmonary disease with mild cognitive impairment and dementia[J]. Curr Opin Pulm Med, 2018, 24: 173-178.
9 van Beers M, Janssen DJA, Gosker HR, et al. Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions[J]. Expert Rev Respir Med, 2018, 12(12): 1061-1074.
10 Turan O, Turan PA, Mirici A. Parameters affffecting inhalation therapy adherence in elderly patients with chronic obstructive lung disease and asthma[J]. Geriatr Gerontol Int, 2017, 17: 999-1005.
11 Abebaw M Yohannes, Michelle N Eakin, Janet T Holbrook, et al. Association of mild cognitive impairment and characteristic of COPD and overall health status in a cohort study[J]. Expert Rev Respir Med, 2021, 15: 153-159.
12 Xie Fei, Xie Lixin. COPD and the risk of mild cognitive impairment and dementia: a cohort study based on the Chinese Longitudinal Health Longevity Survey[J]. Int J Chron Obstruct Pulmon Dis, 2019, 14: 403-408.
13 Roberts RO, Knopman DS, Mielke MM, et al. Higher risk of progression to dementia in mild cognitive impairment cases who revert to normal[J]. Neurology, 2014, 82: 317-325.
14 Dag E, Bulcun E, Turkel Y, et al. Factors influencing cognitive function in subjects with COPD[J]. Respir Care, 2016, 61(8): 1044-11050.
15 郁芳芳, 王 兰, 刘澄英, 等. 蒙特利尔认知评估量表在筛查慢阻肺患者轻度认知功能障碍的价值[J]. 临床肺科杂志, 2018, 23(11): 113-115.
16 Dodd JW, Broek MVD. Cognitive loss in stable non-hypoxaemic patients with moderate chronic obstructive pulmonary disease[J].Thorax,2010, 65(Suppl 4): A139-A140.
17 Chakraborty SI, Kaur S, Guha S, et al. The multifaceted roles of neutrophil gelatinase associated lipocalin(NGAL)in inflammation and cancer[J]. Biochim Biophys Acta, 2012, 1826(1): 129-169.
18 Bhusal Anup, Lee Won-Ha, Suk Kyoungho. Lipocalin-2 in diabetic complications of the nervous system: physiology, pathology, and beyond[J]. Front Physiol, 2021, 12: 638112.
19 Zhang Meng-Xia, Wang Li, Zheng Lei, et al. LCN2 Is a Potential biomarker for radioresistance and recurrence in nasopharyngeal carcinoma[J]. Front Oncol, 2020, 10: 605777.
20 Moschen AR, Adolph TE, Gerner RR, et al. Lipocalin-2: A Master Mediator of Intestinal and Metabolic Inflammation[J]. Trends Endocrinol Metab, 2017, 28(5): 388-397.
21 Abdallah Emad, Waked Emam, Al-Helal Bassam, et al. Novel troponin-like biomarkers of acute kidney injury[J]. Saudi J Kidney Dis Transpl, 2013, 24: 1111-1124.
22 Lippi G, Meschi T, Nouvenne A, et al. Neutrophil gelatinase-associated lipocalin in cancer[J]. Adv Clin Chem, 2014, 64: 179-219.
23 Nakai Michael E, Denham Joshua, Prestes Priscilla R, et al. Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting[J]. Sci Rep, 2021, 11: 4056.
24 Dittrich AM, Meyer HA, Hamelmann E, et al. The role of lipocalins in airway disease[J].Clin Exp Allergy, 2013, 43(5): 503-511.
25 Sevéus L, Amin K, Peterson CG, et al. Human neutrophil lipocalin(HNL)is a specific granule constituent of the neutrophil granulocyte. Studies in bronchial and lung parenchymal tissue and peripheral blood cells[J]. Histochem Cell Biol, 1997, 107(5): 423-432.

备注/Memo

备注/Memo:
基金项目: 江苏省六大人才高峰项目(WSN-015)
通信作者: 杜 强, Email: jingshuyue@163.com
更新日期/Last Update: 2022-02-20