|本期目录/Table of Contents|

[1]王健,赵佳,赵蕾,等.NSCLC组织SFRP1和β-连环蛋白表达与临床病理特征[J].中华肺部疾病杂志,2022,(01):85-87.[doi:10.3877/cma.j.issn.1674-6902.2022.01.024]
点击复制

NSCLC组织SFRP1和β-连环蛋白表达与临床病理特征(PDF)

《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2022年01期
页码:
85-87
栏目:
临床研究
出版日期:
2022-02-20

文章信息/Info

Title:
-
作者:
王健1; 赵佳1; 赵蕾1; 陈伟伟1; 朱劲松1; 张胜利1; 杨辉2
061000 河北,沧州市人民医院呼吸内科1 062550,河北,任丘市第二人民医院呼吸内科2
Author(s):
-
关键词:
非小细胞肺癌;  分泌型卷曲相关蛋白1;  β-连环蛋白
Keywords:
-
分类号:
R563
DOI:
10.3877/cma.j.issn.1674-6902.2022.01.024
摘要:
目的 分析非小细胞肺癌(NSCLC)组织分泌型卷曲相关蛋白1(SFRP1)和β-连环蛋白(β-catenin)表达与临床病理特征及预后的相关性。方法 选取2018年1月至2020年1月收治的35例NSCLC患者,采集患者癌组织和癌旁组织标本。采用免疫组化技术检测癌组织和癌旁组织中SFRP1、β-catenin表达,分析NSCLC患者癌组织SFRP1、β-catenin表达与病理特征的关系,癌组织SFRP1、β-catenin表达与预后的相关性。结果 癌组织SFRP1阳性表达率低于癌旁组织(P<0.05),癌组织β-catenin阳性表达率高于癌旁组织(P<0.05); NSCLC患者癌组织SFRP1、β-catenin表达与分化程度、淋巴结转移、临床分期有关(P<0.05)。35例NSCLC患者总生存率为58.82%,癌组织SFRP1阳性、阴性表达患者生存率分别为84.62%和45.450%,癌组织SFRP1阳性表达与阴性表达患者的生存曲线比较,差异有统计学意义(χ2=5.221,P=0.022); 癌组织β-catenin阳性、阴性表达患者生存率分别为51.72%和100.00%。癌组织β-catenin阳性表达与阴性表达患者的生存曲线比较,差异有统计学意义(χ2=4.828,P=0.028)。结论 NSCLC组织SFRP1、β-catenin表达与分化程度、淋巴结转移、临床分期有关,临床检测癌组织SFRP1、β-catenin表达可用于非小细胞肺癌患者预后评估。
Abstract:
-

参考文献/References:

1 王 笑, 李 鑫, 杨学刚, 等. 非小细胞肺癌微波消融术后血清Caspase-4变化及意义[J/CD]. 中华肺部疾病杂志(电子版), 2020, 13(2): 218-222.
2 Duma N, Santana-Davila R, Molina JR. Non-small cell lung cancer: Epidemiology, screening, diagnosis, and treatment[J]. Mayo Clin Proc, 2019, 94(8): 1623-1640.
3 Arbour KC, Riely GJ. Systemic therapy for locally advanced and metastatic non-small cell lung cancer: A review[J]. JAMA, 2019, 322(8): 764-774.
4 张秀义, 许浩然, 孙亚东. 非小细胞肺癌中p-mTOR,Beclin1及Atg1蛋白表达及其临床意义[J/CD]. 中华肺部疾病杂志(电子版), 2020, 13(5): 633-638.
5 高 岩, 辛雯艳, 王 蓓, 等. 微小RNA708靶向调控FOXO3表达及对非小细胞肺癌细胞增殖,侵袭和迁移的影响[J]. 临床肿瘤学杂志, 2019, 24(10): 886-890.
6 Clemenceau A, Diorio C, Durocher F. Role of secreted frizzled-related protein 1 in early mammary gland tumorigenesis and its regulation in breast microenvironment[J]. Cells, 2020, 9(1): 208-215.
7 Krishnamurthy N, Kurzrock R. Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors[J]. Cancer Treat Rev, 2018, 62(3): 50-60.
8 Li Y, Chen F, Shen W, et al. WDR74 induces nuclear β-catenin accumulation and activates Wnt-responsive genes to promote lung cancer growth and metastasis[J]. Cancer Lett, 2020, 471(10): 103-115.
9 陆 舜, 纪文翔, 虞永峰. 2014版《NCCN非小细胞肺癌临床实践指南》更新解读[J]. 中国医师进修杂志, 2015, 38(38): 318-320.
10 弗赖雷, 卡格尔, 欧 文, 等. 肺肿瘤病理学图谱:组织病理学、细胞病理学、内镜和影像学[M]. 北京市: 北京科学技术出版社, 2013: 96-97.
11 Broderick SR. Adjuvant and neoadjuvant immunotherapy in non-small cell lung cancer[J]. Thorac Surg Clin, 2020, 30(2): 215-220.
12 Sankar K, Gadgeel SM, Qin A. Molecular therapeutic targets in non-small cell lung cancer [J]. Expert Rev Anticancer Ther, 2020, 20(8): 647-661.
13 刘天艺. Oct4 mRNA在非小细胞肺癌患者肿瘤组织的表达与病理特征的相关性分析[J/CD]. 中华肺部疾病杂志(电子版), 2019, 12(3): 342-344.
14 Lee SS, Cheah YK. The interplay between microRNAs and cellular components of tumour microenvironment(TME)on non-small-cell lung cancer(NSCLC)progression[J]. J Immunol Res, 2019, 588(6): 151-156.
15 Kohsaka S, Petronczki M, Solca F, et al. Tumor clonality and resistance mechanisms in EGFR mutation-positive non-small-cell lung cancer: implications for therapeutic sequencing[J]. Future Oncol, 2019, 15(6): 637-652.
16 Clamon G, Zeitler W, An J, et al. Transformational changes between non-small cell and small cell lung cancer-biological and clinical relevance- a review[J]. Am J Clin Oncol, 2020, 43(9): 670-675.
17 Yang F, Xu J, Li H, et al. FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation[J]. Nat Commun, 2019, 10(1): 1382-1391.
18 Cheng LC, Chao YJ, Overman MJ, et al. Increased expression of secreted frizzled related protein 1(SFRP1)predicts ampullary adenocarcinoma recurrence[J]. Sci Rep, 2020, 10(1): 1325-1330.
19 Wang Z, Li R, He Y, et al. Effects of secreted frizzled-related protein 1 on proliferation, migration, invasion, and apoptosis of colorectal cancer cells[J]. Cancer Cell Int, 2018, 18(6): 48-56.
20 Cho SH, Kuo IY, Lu PF, et al. Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness[J]. Cell Death Dis, 2018, 9(9): 868-874.
21 Wang J, Zhao J, Zhu J, et al. Hypoxic non-small-cell lung cancer cell-secreted exosomal microRNA-582-3p drives cancer cell malignant phenotypes by targeting secreted frizzled-related protein 1[J]. Cancer Manag Res, 2020, 12(7): 10151-10161.
22 Huang JQ, Wei FK, Xu XL, et al. SOX9 drives the epithelial-mesenchymal transition in non-small-cell lung cancer through the Wnt/β-catenin pathway[J]. J Transl Med, 2019, 17(1): 143-150.
23 张冉冉, 朱 琳, 于佳晴, 等. 低表达UHRF1通过Wnt/β-catenin信号通路抑制非小细胞肺癌细胞增殖能力的研究[J]. 国际免疫学杂志, 2019, 42(4): 365-370.
24 Pan J, Fang S, Tian H, et al. lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling[J]. Mol Cancer, 2020, 19(1): 9-15.
25 Katoh M. Multi-layered prevention and treatment of chronic inflammation,organ fibrosis and cancer associated with canonical WNT/β-catenin signaling activation(Review)[J]. Int J Mol Med, 2018, 42(2): 713-725.

备注/Memo

备注/Memo:
基金项目: 2017年沧州市科学技术研究与发展指导计划项目(172302102)
通信作者: 王 健, Email: q147873579325@sina.com
更新日期/Last Update: 2022-02-20