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[1]张 楠,周柄全.经鼻高流量氧疗联用呼吸兴奋剂在AECOPD无创正压通气中的意义[J].中华肺部疾病杂志,2022,(03):376-378.[doi:10.3877/cma.j.issn.1674-6902.2022.03.022]
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经鼻高流量氧疗联用呼吸兴奋剂在AECOPD无创正压通气中的意义(PDF)

《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2022年03期
页码:
376-378
栏目:
临床研究
出版日期:
2022-06-20

文章信息/Info

Title:
-
作者:
张 楠1; 周柄全2
214001 江苏,无锡市第二人民医院急诊科1、药剂科2
Author(s):
-
关键词:
经鼻高流量氧疗;  呼吸兴奋剂;  急性加重; 肺疾病; 慢性阻塞性;  无创正压通气;  应用效果
Keywords:
-
分类号:
R563
DOI:
10.3877/cma.j.issn.1674-6902.2022.03.022
摘要:
目的 分析经鼻高流量氧疗联用呼吸兴奋剂在慢性阻塞性肺疾病急性加重(AECOPD)无创正压通气中的意义。方法 选择2018年3月至2021年4月我院收治的AECOPD患者78例,随机分为观察组41例与对照组37例。对照组给予无创正压通气联合呼吸兴奋剂治疗。观察组在对照组的基础上给予经鼻高流量氧疗。对比治疗前、治疗后24 h两组PaCO2、PaO2水平、改良呼吸困难指数(mMRC)、TNF-α以及IL-1β水平。结果 观察组总有效率(95.12%)比对照组(75.68%)高(P<0.05); 两组治疗前的PaCO2、PaO2水平、血清TNF-α、IL-1β水平比较无显著性差异(P>0.05); 两组治疗后24 h的PaCO2水平、血清TNF-α、IL-1β水平均降低(P<0.05); 两组治疗后24 h的PaO2水平均升高(P<0.05); 治疗前,两组mMRC评分比较P>0.05; 治疗后24 h,两组mMRC评分降低(P<0.05)。结论 经鼻高流量氧疗联用呼吸兴奋剂在AECOPD患者无创正压通气治疗中疗效显著,改善患者的血气指标与呼吸困难程度,减轻机体炎症因子水平。
Abstract:
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参考文献/References:

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备注/Memo

备注/Memo:
基金项目: 江苏省自然科学基金青年基金(BK20170202)
通信作者: 张 楠, Email: zhangnan170306@163.com
更新日期/Last Update: 2022-06-20