|本期目录/Table of Contents|

[1]王庭丰,陈爱民,陈 欣,等.CTC水平与非小细胞肺癌临床及病理特征的关系[J].中华肺部疾病杂志,2022,(05):676-678.[doi:10.3877/cma.j.issn.1674-6902.2022.05.014]
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CTC水平与非小细胞肺癌临床及病理特征的关系(PDF)

《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2022年05期
页码:
676-678
栏目:
临床研究
出版日期:
2022-10-20

文章信息/Info

Title:
-
作者:
王庭丰; 陈爱民; 陈 欣; 周芸娜; 颜红莲; 夏晓阳
239000 滁州,安徽医科大学附属滁州医院(滁州市第一人民医院)肿瘤内三科
Author(s):
-
关键词:
非小细胞肺癌; 晚期;  外周血循环肿瘤细胞;  临床病理特征;  化疗疗效
Keywords:
-
分类号:
R734.2
DOI:
10.3877/cma.j.issn.1674-6902.2022.05.014
摘要:
目的 分析外周血循环肿瘤细胞(CTC)水平与晚期非小细胞肺癌(NSCLC)临床病理特征的关系。方法 选取2018年1月至2021年1月我院收治的晚期NSCLC患者56例为对象,采用GP化疗方式,3个疗程后进行全面检查及疗效评估,根据疗效评估结果分为对照组21例,观察组35例。化疗前抽取患者空腹肘静脉血富集鉴定并检测血液中的CTC水平,分析CTC水平与临床特征之间的关系,比较两组外周血CTC水平,采用多因素Logistic回归分析影响NSCLC患者疗效的危险因素。结果 56例NSCLC患者平均外周血CTC数目为(19.26±2.59)个/7.5 ml; 外周血CTC水平与淋巴结转移、TNM分期相关(P<0.05); CR患者1例,PR患者20例,PD患者35例。有效(CR+PR)21例,无效35例; 与对照组比较,观察组外周血CTC计数水平升高(P<0.05); 多因素Logistic分析显示,发生淋巴结转移、CTC水平高是NSCLC患者治疗无效的危险因素(OR=4.033、5.010,P<0.05)。结论 NSCLC患者CTC水平与分期晚、淋巴结转移等临床病理参数有关,是化疗治疗无效的危险因素,用于NSCLC化疗效果分析有意义。
Abstract:
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备注/Memo

备注/Memo:
基金项目: 安徽省自然科学基金项目(1808063MH126)
通信作者: 王庭丰, Email: wangtf007700@163.com
更新日期/Last Update: 2022-10-20