|本期目录/Table of Contents|

[1]惠 盼,谯钰琪,南岩东.ITGA5与肿瘤关系的研究进展[J].中华肺部疾病杂志,2022,(05):759-761.[doi:10.3877/cma.j.issn.1674-6902.2022.05.040]
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ITGA5与肿瘤关系的研究进展(PDF)

《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2022年05期
页码:
759-761
栏目:
综述
出版日期:
2022-10-20

文章信息/Info

Title:
-
作者:
惠 盼1; 2; 谯钰琪1; 2; 南岩东2
716000 延安,延安大学医学院1 710038 西安,空军军医大学唐都医院呼吸与危重症医学科2
Author(s):
-
关键词:
整合素α5;  肿瘤;  治疗靶点
Keywords:
-
分类号:
R734.2
DOI:
10.3877/cma.j.issn.1674-6902.2022.05.040
摘要:
-
Abstract:
-

参考文献/References:

1 陶 韬, 赵麟丰, 王 彦, 等. ADAM33对人肺成纤维细胞增殖、周期、凋亡的影响及IL-4对其表达影响的研究[J/CD]. 中华肺部疾病杂志(电子版), 2015, 8(3): 28-31.
2 Barczyk M, Carracedo S, Gullberg D. Integrins[J]. Cell Tissue Res, 2010, 339(1): 269-280.
3 Kadry YA, Calderwood DA. Chapter 22: Structural and signaling functions of integrins[J]. Biochim Biophys Acta Biomembr, 2020, 1862(5): 183206.
4 Ganguly KK, Pal S, Moulik S, et al. Integrins and metastasis[J]. Cell Adh Migr, 2013, 7(3): 251-261.
5 van der Flier A, Sonnenberg A. Function and interactions of integrins[J]. Cell Tissue Res, 2001, 305(3): 285-298.
6 Schnittert J, Bansal R, Storm G, et al. Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery[J]. Adv Drug Deliv Rev, 2018, 129: 37-53.
7 Nam EH, Lee Y, Moon B, et al. Twist1 and AP-1 cooperatively upregulate integrin alpha5 expression to induce invasion and the epithelial-mesenchymal transition[J]. Carcinogenesis, 2015, 36(3): 327-337.
8 Qin L, Chen X, Wu Y, et al. Steroid receptor coactivator-1 upregulates integrin alpha(5)expression to promote breast cancer cell adhesion and migration[J]. Cancer Res, 2011, 71(5): 1742-1751.
9 Zhang CZ, Wang XD, Wang HW, et al. Sorafenib inhibits liver cancer growth by decreasing mTOR, AKT, and PI3K expression[J]. J BUON, 2015, 20(1): 218-222.
10 Yu R, Li Z, Zhang C, et al. Elevated limb-bud and heart development (LBH)expression indicates poor prognosis and promotes gastric cancer cell proliferation and invasion via upregulating Integrin/FAK/Akt pathway[J]. Peer J, 2019, 7: e6885.
11 Kim S, Kang H Y, Nam EH, et al. TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways[J]. Carcinogenesis, 2010,31(4):597-606.
12 Garmy-Susini B, Varner JA. Roles of integrins in tumor angiogenesis and lymphangiogenesis[J]. Lymphat Res Biol, 2008, 6(3-4): 155-163.
13 Murphy PA, Begum S, Hynes RO. Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors[J]. PLoS One, 2015, 10(3): e120872.
14 Shih SC, Zukauskas A, Li D, et al. The L6 protein TM4SF1 is critical for endothelial cell function and tumor angiogenesis[J]. Cancer Res, 2009, 69(8): 3272-3277.
15 Saatci O, Kaymak A, Raza U, et al. Targeting lysyl oxidase(LOX)overcomes chemotherapy resistance in triple negative breast cancer[J]. Nat Commun, 2020, 11(1): 2416.
16 Zhao D, Qiao J, He H, et al. TFPI2 suppresses breast cancer progression through inhibiting TWIST-integrin alpha5 pathway[J]. Mol Med, 2020, 26(1): 27.
17 Xiao Y, Li Y, Tao H, et al. Integrin alpha5 down-regulation by miR-205 suppresses triple negative breast cancer stemness and metastasis by inhibiting the Src/Vav2/Rac1 pathway[J]. Cancer Lett, 2018, 433: 199-209.
18 Li X Q, Lu JT, Tan CC, et al. RUNX2 promotes breast cancer bone metastasis by increasing integrin alpha5-mediated colonization[J]. Cancer Lett, 2016, 380(1): 78-86.
19 Zhang XB, Song L, Wen HJ, et al. Upregulation of microRNA-31 targeting integrin alpha5 suppresses tumor cell invasion and metastasis by indirectly regulating PI3K/AKT pathway in human gastric cancer SGC7901 cells [J]. Tumour Biol, 2016,37(6): 8317-8325.
20 Wang JF, Wang Y, Zhang SW, et al. Expression and Prognostic Analysis of Integrins in Gastric Cancer[J]. J Oncol, 2020, 2020: 8862228.
21 Zhu H, Wang G, Zhu H, et al. ITGA5 is a prognostic biomarker and correlated with immune infiltration in gastrointestinal tumors[J]. BMC Cancer, 2021, 21(1): 269.
22 郭亚妹, 徐广贤, 闪明海, 等. 整合素α5的表达下调抑制肝癌Bel-7404细胞的增殖、侵袭及转移[J]. 南方医科大学学报, 2020, 40(6): 893-898.
23 Zhao X, Wu Y, Lv Z. miR-128 modulates hepatocellular carcinoma by inhibition of ITGA2 and ITGA5 expression[J]. Am J Transl Res, 2015, 7(9): 1564-1573.
24 Chen J, Ji T, Wu D, et al. Human mesenchymal stem cells promote tumor growth via MAPK pathway and metastasis by epithelial mesenchymal transition and integrin alpha5 in hepatocellular carcinoma[J]. Cell Death Dis, 2019, 10(6): 425.
25 Yu M, Chu S, Fei B, et al. O-GlcNAcylation of ITGA5 facilitates the occurrence and development of colorectal cancer[J]. Exp Cell Res, 2019, 382(2): 111464.
26 Yoo HI, Kim BK, Yoon SK. MicroRNA-330-5p negatively regulates ITGA5 expression in human colorectal cancer [J]. Oncol Rep, 2016, 36(5): 3023-3029.
27 Gong YZ, Ruan GT, Liao XW, et al. Diagnostic and prognostic values of integrin alpha subfamily mRNA expression in colon adenocarcinoma [J]. Oncol Rep, 2019, 42(3): 923-936.
28 Deng Y, Wan Q, Yan W. Integrin alpha5/ITGA5 Promotes The proliferation, migration, invasion and progression of oral squamous carcinoma by epithelial-mesenchymal transition[J]. Cancer Manag Res, 2019, 11: 9609-9620.
29 Fan QC, Tian H, Wang Y, et al. Integrin-alpha5 promoted the progression of oral squamous cell carcinoma and modulated PI3K/AKT signaling pathway[J]. Arch Oral Biol, 2019, 101: 85-91.
30 Li T, Wu Q, Liu D, et al. miR-27b suppresses tongue squamous cell carcinoma epithelial-mesenchymal transition by targeting ITGA5[J]. Onco Targets Ther, 2020, 13: 11855-11867.
31 Connell B, Kopach P, Ren W, et al. Aberrant integrin alphav and alpha5 expression in prostate adenocarcinomas and bone-metastases is consistent with a bone-colonizing phenotype[J]. Transl Androl Urol, 2020, 9(4): 1630-1638.
32 Yan T, Ye XX. MicroRNA-328-3p inhibits the tumorigenesis of bladder cancer through targeting ITGA5 and inactivating PI3K/AKT pathway[J]. Eur Rev Med Pharmacol Sci, 2019, 23(12): 5139-5148.
33 Zhu T, Chen R, Wang J, et al. The prognostic value of ITGA and ITGB superfamily members in patients with high grade serous ovarian cancer[J]. Cancer Cell Int, 2020, 20: 257.
34 Cui S, Yang CL, Chen DY. LncRNA EWSAT1 Regulates the tumor genesis of NSCLC as a ceRNA by Modulating miR-330-5p/ITGA5 Axis[J]. Biochem Genet, 2021, 59(6): 1441-1456.
35 Kuninty PR, Bansal R, De Geus S, et al. ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer[J]. Sci Adv, 2019, 5(9): x2770.

备注/Memo

备注/Memo:
基金项目: 陕西省重点研发计划(NO.2019SF-009)
唐都医院创新发展基金(2017LCYJ016)
通信作者: 南岩东, Email: 13709205538@163.com
更新日期/Last Update: 2022-10-20