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《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:

期数:

2023年02期

页码:

242-244

栏目:

临床研究

出版日期:

2023-04-20

文章信息/Info

Title:

-

作者:

仇丽敏 胡航 孙云浩 孙健 陈婷婷

224001 江苏,盐城市第一人民医院胸心外科

Author(s):

-

关键词:

非小细胞肺癌;  根治性切除术;  早期复发;  风险预测

Keywords:

-

分类号:

R734.2

DOI:

10.3877/cma.j.issn.1674-6902.2023.02.024

摘要:

目的 分析非小细胞肺癌(non-small cell lung cancer, NSCLC)根治性切除术后复发风险。方法 选取2020年1月至2020年10月我院收治经根治性切除术NSCLC患者72例为对象,将复发23例为观察组,未复发49例为对照组。采用多因素Logistic回归模型分析影响NSCLC患者根治性切除术情况相关因素,构建早期复发风险模型,验证模型效能。结果 观察组TNM分期Ⅱ期～Ⅲ期高于对照组,癌胚抗原(CEA)(26.68±4.53 vs. 23.69±6.04 )ng/ml、中性粒细胞/淋巴细胞比值(NLR)(3.63±0.83 vs. 3.06±0.96)、C反应蛋白/白蛋白(CAR)水平(0.57±0.10 vs. 0.48±0.10)高于对照组(P<0.05); 多因素Logistic分析显示,TNM分期Ⅱ期～Ⅲ期(OR=2.008,95%CI:1.582～2.548)、CEA(OR=2.126,95%CI:1.863～2.426)、NLR(OR=2.578,95%CI:2.252～2.950、CAR(OR=2.008,95%CI:1.582～2.548)为NSCLC患者根治性切除术早期复发的危险因素(P<0.05),预测NSCLC患者根治性切除术后早期复发性指数(C-index)为0.871(95%CI:0.813～0.929),校正曲线实测值与观察值基本相符。结论 TNM分期、CEA、NLR、CAR为NSCLC根治性切除术早期复发的影响因素,复发预测模型具有临床意义。

Abstract:

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参考文献/References:

1 王洪武, 金发光. 晚期非小细胞肺癌多域整合治疗策略[J/CD]. 中华肺部疾病杂志(电子版), 2022, 15(4): 457-461.
2 Hisao Imai, Ryoichi Onozato, Kyoichi Kaira, et al. Course of postoperative relapse in non-small cell lung cancer is strongly associated with post-progression survival[J]. Thorac Cancer, 2021, 12(20): 2740-2748.
3 苏 洁, 徐锦锦, 时会敏. 预后营养指数对原发性非小细胞肺癌患者预后的预测意义及列线图的建立研究[J]. 实用癌症杂志, 2022, 37(6): 926-929.
4 赵坤宇, 亓妍文, 秦国慧, 等. 中性粒细胞淋巴细胞比值和淋巴细胞单核细胞比值对PD-1抑制剂治疗的晚期非小细胞肺癌患者预后的预测价值[J]. 郑州大学学报(医学版), 2022, 57(3): 379-382.
5 中华医学会, 中华医学会肿瘤学分会, 中华医学会杂志社. 中华医学会肺癌临床诊疗指南(2018版)[J]. 中华肿瘤杂志, 2018, 40(12): 935-964.
6 王书航, 王 洁. 2018年V3版NCCN非小细胞肺癌指南更新要点解读[J]. 华西医学, 2018, 33(4): 388-392.
7 David S Ettinger, Douglas E Wood, Dara L Aisner, et al. Non-small cell lung cancer, Version 3.2022, NCCN clinical practice guidelines in oncology[J]. J Natl Compr Canc Netw, 2022, 20(5): 497-530.
8 Yifan Zhong, Yunlang She, Jiajun Deng, et al. Deep learning for prediction of N2 metastasis and survival for clinical stage i non-small cell lung cancer[J]. Radiology, 2022, 302(1): 200-211.
9 Zhicheng Jiao, Hongming Li, Ying Xiao, et al. Integration of deep learning radiomics and counts of circulating tumor cells improves prediction of outcomes of early stage NSCLC patients treated with stereotactic body radiation therapy[J]. Int J Radiat Oncol Biol Phys, 2022, 112(4): 1045-1054.
10 赵方超, 王伟健, 刘建明. 非小细胞肺癌术后复发转移的风险模型构建及预测能力的验证[J]. 肿瘤防治研究, 2020, 47(4): 273-277.
11 Haidan Lan, Leng Zhou, Dongmei Chi, et al. Preoperative platelet to lymphocyte and neutrophil to lymphocyte ratios are independent prognostic factors for patients undergoing lung cancer radical surgery: A single institutional cohort study[J]. Oncotarget, 2017, 8(21): 35301-35310.
12 Sung Chul Lee, Jung Wook Huh, Woo Yong Lee, et al. Prognostic value of serum inflammatory markers in colorectal cancer[J]. Int J Colorectal Dis, 2020, 35(7): 1211-1219.
13 David Hui, Carlos Eduardo Paiva, Egidio G Del Fabbro, et al. Prognostication in advanced cancer: update and directions for future research[J]. Support Care Cancer, 2019, 27(6): 1973-1984.
14 Yusuke Ishibashi, Hironori Tsujimoto, Takahiro Einama, et al. Correlation between immunoinflammatory measures and periostin expression in esophageal squamous cell carcinoma: a single-center, retrospective cohort study[J]. Ann Surg Oncol, 2021, 28(2): 1228-1237.
15 Meng Zhu, Zhimin Ma, Xu Zhang, et al. C-reactive protein and cancer risk: a pan-cancer study of prospective cohort and Mendelian randomization analysis[J]. BMC Med, 2022, 20(1): 301.
16 Zheng Jia-Min, Dai Wei, Lu Ye, et al. Correlation between C-reactive protein/albumin ratio and prognosis in patients with lung adenocarcinoma[J]. J Int Med Res, 2022, 50(6): 3000605221105372.
17 Zhang KP, Zhang X, Zhang Q, et al. Association between the lymphocyte-to-C-reactive protein ratio and survival outcomes in cancer patients with GLIM-defined malnutrition: a multicenter study[J]. J Nutr Health Aging, 2022, 26(9): 847-855.
18 Shuhang Wang, Stefan Zimmermann, Kaushal Parikh, et al. Current diagnosis and management of small-cell lung cancer[J]. Mayo Clin Proc, 2019, 94(8): 1599-1622.
19 M G Dal Bello, R A Filiberti, A Alama, et al. The role of CEA, CYFRA21-1 and NSE in monitoring tumor response to Nivolumab in advanced non-small cell lung cancer(NSCLC)patients[J]. J Transl Med, 2019, 17(1): 74.
20 Ryoichi Miyamoto, Satoshi Inagawa, Naoki Sano, et al. The neutrophil-to-lymphocyte ratio(NLR)predicts short-term and long-term outcomes in gastric cancer patients[J]. Eur J Surg Oncol, 2018, 44(5): 607-612.
21 陶立元, 张 华, 赵一鸣. 列线图的制作要点及其应用[J]. 中华儿科杂志, 2017, 55(5): 323.
22 梁东敏, 洪嘉源, 谢 宁, 等. 青年型非小细胞肺癌的预后影响因素及列线图构建[J]. 滨州医学院学报, 2022, 45(3): 165-170.

备注/Memo

备注/Memo:

通信作者: 胡 航, Email: 273619529@qq.com

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更新日期/Last Update: 2023-04-20