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《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:

期数:

2023年02期

页码:

281-284

栏目:

综述

出版日期:

2023-04-20

文章信息/Info

Title:

-

作者:

李多 郝昭昭 陈延伟 南岩东

710038 西安,空军军医大学唐都医院呼吸内科

Author(s):

-

关键词:

Wnt/β-Catenin通路;  非小细胞肺癌;  转移机制

Keywords:

-

分类号:

R734.2

DOI:

10.3877/cma.j.issn.1674-6902.2023.02.037

摘要:

-

Abstract:

-

参考文献/References:

1 吴国明, 钱桂生. 非小细胞肺癌靶向治疗研究进展及新理念[J/CD]. 中华肺部疾病杂志(电子版), 2019, 12(4): 405-408.
2 马蓉蓉, 明宗娟, 李 维, 等. 肺腺癌病理类型转化特征及耐药机制分析[J/CD]. 中华肺部疾病杂志(电子版), 2022,15(6): 782-786.
3 Tamura T, Kurishima K, Nakazawa K, et al. Specific organ metastases and survival in metastatic non-small-cell lung cancer[J]. Mol Clin Oncol, 2015, 3(1): 217-221.
4 Ko EC, Raben D, Formenti SCJC. The integration of radiotherapy with immunotherapy for the treatment of non-small cell lung cancer[J]. Clin Cancer Res, 2018, 24(23): 5792-5806.
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6 Agostino M, Pohl SÖ. The structural biology of canonical Wnt signalling[J]. Biochem Soc Trans, 2020, 48(4): 1765-1780.
7 Zheng H, Ning Y, Yang Y, et al. Aberrant expression of β-catenin correlates with infiltrating immune cells and prognosis in NSCLC[J]. Pathol Oncol Res, 2021, 27: 1609981.
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14 Yang Y, Sun Y, Wu Y, et al. Downregulation of miR-3127-5p promotes epithelial-mesenchymal transition via FZD4 regulation of Wnt/β-catenin signaling in non-small-cell lung cancer[J]. Mol Carcinog, 2018, 57(7): 842-853.
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19 Olsen JJ, Pohl SÖ, Deshmukh A, et al. The role of wnt sgnalling in angiogenesis[J]. Clin Biochem Rev, 2017, 38(3): 131-142.
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21 Shukla S, Sinha S, Khan S, et al. Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis[J]. Sci Rep, 2016, 6: 21860.
22 Jaime G Fernández, Diego A Rodríguez, Manuel Valenzuela, et al. Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription[J]. Mol Cancer, 2014, 13: 209.
23 Eun-Jin Yeo, Luca Cassetta, Bin-Zhi Qian, et al. Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer[J]. Cancer Res, 2014, 74(11): 2962-2973.
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25 Judit Rapp, Luca Jaromi, Krisztian Kvell, et al. WNT signaling-lung cancer is no exception[J]. Respir Res, 2017, 18(1): 167.
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27 Don X Nguyen, Anne C Chiang, Xiang H-F Zhang, et al. WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis[J]. Cell, 2009, 138(1): 51-62.
28 Huanhuan Li, Fan Tong, Rui Meng, et al. E2F1-mediated repression of WNT5A expression promotes brain metastasis dependent on the ERK1/2 pathway in EGFR-mutant non-small cell lung cancer[J]. Cell Mol Life Sci, 2021, 78(6): 2877-2891.
29 Hui-Juan Zhang, Wen-Jing Chang, Cai-Yun Jia, et al. Destrin contributes to lung adenocarcinoma progression by activating Wnt/β-catenin signaling pathway[J]. Mol Cancer Res, 2020,18(12): 1789-1802.
30 Kelin She, Wensheng Yang, Mengna Li, et al. FAIM2 Promotes non-small cell lung cancer cell growth and bone metastasis by activating the Wnt/β-catenin pathway[J]. Front Oncol, 2021, 11: 690142.
31 Liyun Liu, Hongrui Zhu, Yahui Liao, et al. Inhibition of Wnt/β-catenin pathway reverses multi-drug resistance and EMT in Oct4(+)/Nanog(+)NSCLC cells[J]. Biomed Pharmacother, 2020, 127: 110225.
32 Liyun Gong, Junwei Song, Xi Lin, et al. Serine-arginine protein kinase 1 promotes a cancer stem cell-like phenotype through activation of Wnt/β-catenin signalling in NSCLC[J]. J Pathol, 2016, 240(2): 184-196.
33 Xiong Shu, Meng Chen, Shi-Ya Liu, et al. Palladin promotes cancer stem cell-like properties in lung cancer by activating Wnt/β-catenin signaling[J]. Cancer Med, 2022, 12(4): 4510-4520.
34 Jie Su, Shifei Wu, Haiyang Wu, et al. CD44 is functionally crucial for driving lung cancer stem cells metastasis through Wnt/β-catenin-FoxM1-Twist signaling[J]. Mol Carcinog, 2016, 55(12): 1962-1973.
35 Yunxia Ma, Rumyana Marinkova, Miljana Nenkov, et al. Tumor-intrinsic PD-L1 exerts an oncogenic function through the activation of the Wnt/β-catenin pathway in human non-small cell lung cancer[J]. Int J Mol Sci, 2022, 23(19): 11031.
36 Andreas H Scheel, Sascha Ansén, Anne M Schultheis, et al. PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations[J]. Oncoimmunology, 2016, 5(5): e1131379.
37 Pei-Shan Hung, Ming-Hung Huang, Yuan-Yeh Kuo, et al. The inhibition of wnt restrain KRAS(G12V)-driven metastasis in non-small-cell lung cancer[J]. Cancers(Basel), 2020, 12(4): 837.
38 Qiang Wang, Jinrong Liao, Zhiyong He, et al. LHX6 affects erlotinib resistance and migration of EGFR-mutant non-small-cell lung cancer HCC827 cells through suppressing Wnt/β-catenin signaling[J]. Onco Targets Ther, 2020, 13: 10983-10994.
39 Junchao Cai, Lishan Fang, Yongbo Huang, et al. Publisher Correction: Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC[J]. Nat Commun, 2018, 9: 16196.
40 Yang Wang, Bo He, Yan Dong, et al. Homeobox-A13 acts as a functional prognostic and diagnostic biomarker via regulating P53 and Wnt signaling pathways in lung cancer[J]. Cancer Biomark, 2021, 31(3): 239-254.
41 Neng Jiang, Chang Zou, Ying Zhu, et al. HIF-1ɑ-regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt/β-catenin and Notch signaling[J]. Theranostics, 2020, 10(6): 2553-2570.
42 Rachelle W Johnson, Alyssa R Merkel, Jonathan M Page, et al. Wnt signaling induces gene expression of factors associated with bone destruction in lung and breast cancer[J]. Clin Exp Metastasis, 2014, 31(8): 945-959.

备注/Memo

备注/Memo:

基金项目: 陕西省重点研发计划(2019SF-009)
唐都医院高层次人才启动项目(2021YFJH0011)
通信作者: 南岩东, Email: nanyanong2008@163.com

常用功能

更新日期/Last Update: 2023-04-20