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《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:

期数:

2023年05期

页码:

697-699

栏目:

临床研究

出版日期:

2023-10-20

文章信息/Info

Title:

-

作者:

何 花¹; 周玉皆²; 李 田¹

210029 南京,南京胸科医院胸科院区¹
210008 南京, 南京鼓楼医院²

Author(s):

-

关键词:

鸦胆子油乳;  培美曲塞二钠+卡铂方案;  非小细胞肺癌;  免疫;  炎症因子

Keywords:

-

分类号:

R734.2

DOI:

10.3877/cma.j.issn.1674-6902.2023.05.024

摘要:

目的 分析鸦胆子油乳辅助培美曲塞二钠+卡铂(PC方案)化疗对非小细胞肺癌(non-small cell lung cancer, NSCLC)免疫功能和炎症因子的影响。方法 选取2020年2月至2022年10月我院收治的NSCLC患者53例,随机分为观察组27例和对照组26例。观察组采取鸦胆子油乳辅助PC化疗方案,对照组采取PC化疗方案,分析两组治疗前后免疫功能、炎症因子指标、有效率及不良反应。结果 两组治疗前免疫细胞阳性率和CD4⁺/CD8⁺比值差异无统计学意义(P>0.05),两组治疗后CD3⁺、CD4⁺阳性率及CD4⁺/CD8⁺降低,CD8⁺升高,观察组免疫功能变化幅度小于对照组(P<0.05); 观察组IL-6(18.76±4.20)ng/L vs.(29.15±4.77)ng/L、IL-10(16.62±3.07)ng/L vs.(18.83±3.49)ng/L、CRP(16.89±3.56)mg/L vs.(23.14±3.84)mg/L、TNF-α(221.58±23.98)ng/L vs.(258.02±28.14)ng/L较对照组低(P<0.05); 观察组完全缓解率(40.74% vs. 30.77%),部分缓解率(33.33% vs. 15.38%),稳定率(22.22% vs. 42.31%),恶化率(3.70% vs. 11.54%),总有效率(74.07% vs. 46.15%),优于对照组(χ²=4.316,P=0.038)。不良反应发生率观察组较对照组(25.93% vs. 53.85%),(P=0.05)。结论 鸦胆子油乳辅助PC化疗方案可有效增强NSCLC免疫功能,降低炎症因子水平,提高临床疗效,降低不良反应发生率,具有临床意义。

Abstract:

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备注/Memo

备注/Memo:

通信作者: 李 田, Email: 13701409828@163.com

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更新日期/Last Update: 2023-10-20