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[1]尚明煦,魏丽娟,是若春.血清CRP、BNP、PCT与脓毒症并发ALI程度的相关性[J].中华肺部疾病杂志,2023,(06):766-769.[doi:10.3877/cma.j.issn.1674-6902.2023.06.004]
　Shang Mingxu,Wei Lijuan,Shi Ruochun..Correlation of serum CRP, BNP, PCT between sepsis and acute lung injury[J].,2023,(06):766-769.[doi:10.3877/cma.j.issn.1674-6902.2023.06.004]
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血清CRP、BNP、PCT与脓毒症并发ALI程度的相关性(PDF)

《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2023年06期
页码:
766-769
栏目:
论著
出版日期:
2023-12-20

文章信息/Info

Title:
Correlation of serum CRP, BNP, PCT between sepsis and acute lung injury
作者:
尚明煦; 魏丽娟; 是若春
100007 北京,北京市第六医院重症医学科
Author(s):
Shang Mingxu;  Wei Lijuan;  Shi Ruochun.
Department of Intensive Care Medicine, Beijing Sixth Hospital, Beijing 100007, China
关键词:
脓毒症;  C反应蛋白;  急性肺损伤;  降钙素原;  B型脑钠肽
Keywords:
Sepsis;  C-reactive protein;  Acute lung injury;  Procalcitonin;  B type brain natriuretic peptide
分类号:
R563
DOI:
10.3877/cma.j.issn.1674-6902.2023.06.004
摘要:
目的 分析血清C反应蛋白(C-reactive protein, CRP)、B型脑钠肽(B-type brain natriuretic peptide, BNP)及降钙素原(procalcitonin, PCT)与脓毒症急性肺损伤(acute lung injury, ALI)程度的相关性。方法 选取2019年1月至2022年12月我院收治的脓毒症患者53例为对象,其中并发肺损伤者32例,无肺损伤者21例; 并发肺损伤者根据急性生理学与慢性健康状况(APACHE Ⅱ)评分标准分为低危组15例、高危组17例,根据临床预后分为预后好26例与预后差6例。测定血清CRP、PCT及BNP水平,对比CRP、BNP、PCT水平及APACHE Ⅱ评分,分析检测指标与联合检测脓毒症并ALI预后。 结果 肺损伤者CRP(72.98±2.44 vs. 15.58±3.21)μg/ml、PCT(4.18±0.16 vs. 0.41±0.11)ng/ml、BNP水平(852.68±51.47 vs. 205.58±45.59)ng/L及APACHE Ⅱ评分(14.98±2.15 vs. 8.66±1.12)比较(P<0.05); 高危组CRP(142.65±15.96 vs. 68.21±8.45)μg/ml、PCT(10.09±1.33 vs. 2.08±0.34)ng/ml、BNP水平(1 425.52±95.44 vs. 796.54±45.59)ng/L及APACHE Ⅱ评分(21.65±3.01 vs. 13.14±1.02)比较(P<0.05); 预后差者CRP(123.65±5.47 vs. 70.58±3.12)μg/ml、PCT(12.18±1.35 vs. 4.69±0.84)ng/ml、BNP水平(1 329.18±91.41 vs. 709.54±60.58)ng/L及APACHE Ⅱ评分(19.52±3.97 vs. 13.36±3.48)分较预后好者(P<0.05); 联合检测对脓毒症并ALI预后不佳的诊断特异度、灵敏度分别为77.89%、83.92%,曲线下面积(AUC)为0.859(95%CI:0.779～0.935)。 结论 血清CRP、BNP及PCT检测可反映脓毒症ALI程度,判断预后,具有临床意义。
Abstract:
Objective To analyze the correlation of serum C-reactive protein(CRP), B-type brain natriuretic peptide(BNP)and procalcitonin(PCT)between acute lung injury(ALI)and sepsis. Methods All of 53 patients with sepsis admitted to our hospital from January 2019 to December 2022 were selected as the subjects, including 32 patients with concurrent lung injury and 21 patients without concurrent lung injury. Patients with lung injury were divided into low-risk group 15 cases and high-risk group 17 cases according to acute physiology and chronic health status(APACHE Ⅱ)scoring criteria, and were divided into good prognosis 26 cases and poor prognosis 6 cases according to clinical prognosis. The levels of serum CRP, PCT and BNP were determined, and the levels of CRP, BNP, PCT and APACHEⅡ scores of each group were compared. The application value of single detection and combined detection in evaluating the prognosis of sepsis and acute lung injury was analyzed. Results CRP(72.98±2.44 vs. 15.58±3.21)μg/ml, PCT(4.18±0.16 vs. 0.41±0.11)ng/ml, BNP(852.68±51.47)levels in patients with lung injury vs. 205.58±45.59)ng/L and APACHE Ⅱ scores(14.98±2.15 vs. 8.66±1.12)were higher than those without lung injury(P<0.05). The levels of CRP(142.65±15.96 vs. 68.21±8.45)μg/ml, PCT(10.09±1.33 vs. 2.08±0.34)ng/ml and BNP(1 425.52±95.44 vs. 796.54±45.59)ng/L were found in high-risk patients and APACHE Ⅱ scores(21.65±3.01 vs. 13.14±1.02)were higher(P<0.05). The levels of CRP(123.65±5.47 vs. 70.58±3.12)μg/ml, PCT(12.18±1.35 vs. 4.69±0.84)ng/ml and BNP(1 329.18±91.41 vs. 709.54±60.58)ng/L were found in patients with poor prognosis and APACHE Ⅱ scores(19.52±3.97 vs. 13.36±3.48)were higher than those of good prognosis(P<0.05). The diagnostic specificity and sensitivity of combined detection for sepsis and acute lung injury were 77.89% and 83.92%, respectively, and the area under the curve(AUC)was 0.859(95%CI: 0.779～0.935), which was higher than that of single detection. Conclusion The severity of acute lung injury and sepsis is detected by serum CRP, BNP and PCT accurately, which has clinical significance for prognosis assessment.

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备注/Memo

备注/Memo:
基金项目: 国家自然科学基金资助项目(42077387)
通信作者: 是若春, Email: jinxier@163.com
更新日期/Last Update: 2023-12-20