|本期目录/Table of Contents|

[1]闫卫国,姜 颖,李 叶.血清外泌体circ-BPTF对COPD急性加重期预后分析[J].中华肺部疾病杂志,2023,(06):818-821.[doi:10.3877/cma.j.issn.1674-6902.2023.06.015]
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血清外泌体circ-BPTF对COPD急性加重期预后分析(PDF)

《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2023年06期
页码:
818-821
栏目:
临床研究
出版日期:
2023-12-20

文章信息/Info

Title:
-
作者:
闫卫国; 姜 颖; 李 叶
830000 乌鲁木齐,新疆医科大学第四附属医院急诊科
Author(s):
-
关键词:
外泌体;  环状RNA;  急性加重期; 肺疾病; 慢性阻塞性;  预后;  炎症
Keywords:
-
分类号:
R563
DOI:
10.3877/cma.j.issn.1674-6902.2023.06.015
摘要:
目的 分析血清外泌体环状RNA BPTF(circ-BPTF)对慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease, AECOPD)预后的意义。方法 选取2020年1月至12月我院收治的53例AECOPD患者为对象。RT-PCR检测血清外泌体circ-BPTF水平,全自动生化检测仪检测白细胞介素6(interleukin-6, IL-6)和降钙素原(procalcitonin, PCT)水平。Logistic多因素分析对预后的影响因素; 受试者工作特征曲线(ROC)分析血清外泌体circ-BPTF预后; Pearson法分析外泌体circ-BPTF与IL-6、PCT的相关性。结果 观察组外泌体circ-BPT(1.89±0.39)、IL-6(14.27±6.71)pg/ml、PCT(0.54±0.18)ng/ml,对照组外泌体circ-BPT(1.03±0.23)、IL-6(11.12±3.03)pg/ml、PCT(0.43±0.10)ng/ml(P<0.05); 冠心病、糖尿病、消化道出血、肺功能分级、外泌体circ-BPT水平、IL-6水平、PCT水平是AECOPD预后差(P<0.05)。外泌体circ-BPTF预测AECOPD预后的ROC曲线下面积为0.870(95%CI:0.798～0.916),灵敏度0.771(95%CI:0.626～0.807),特异度0.692(95%CI:0.609～0.769)。血清外泌体circ-BPTF水平分别与IL-6水平(r=0.239,P=0.008)、PCT水平(r=0.219,P=0.016)呈正相关。结论 外泌体circ-BPTF预后不佳AECOPD中表达升高,对AECOPD预后具有意义。
Abstract:
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参考文献/References:

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备注/Memo

备注/Memo:
基金项目: 新疆维吾尔自治区科学技术厅新疆公共卫生关键技术研发与防疫体系建设专项(2022A02003)
通信作者: 闫卫国, Email: ywg8831920@163.com
更新日期/Last Update: 2023-12-20