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[1]王石林,叶继章,丘向艳,等.慢性阻塞性肺疾病真菌感染风险早期预测分析[J].中华肺部疾病杂志,2024,(05):773-776.[doi:10.3877/cma.j.issn.1674-6902.2024.05.018]
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慢性阻塞性肺疾病真菌感染风险早期预测分析(PDF)

《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2024年05期
页码:
773-776
栏目:
临床研究
出版日期:
2024-10-25

文章信息/Info

Title:
-
作者:
王石林; 叶继章; 丘向艳; 陈桂青; 邹晓敏
516001 惠州,惠州市中心人民医院老年科
Author(s):
-
关键词:
肺疾病; 慢性阻塞性;  真菌感染;  风险预测;  入院时血糖;  低白蛋白血症;  抗生素
Keywords:
-
分类号:
R563
DOI:
10.3877/cma.j.issn.1674-6902.2024.05.018
摘要:
目的 分析慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)真菌感染风险的预测。方法 选取2022年1月至2023年12月我院收治的58例COPD患者为对象,真菌感染21例为观察组,未感染真菌37例为对照组,比较两组患者基线资料,采用Logistic回归分析影响COPD患者真菌感染风险的危险因素,构建预测模型。结果 观察组入院时血糖(11.75±1.42)mmol/l、血清降钙素原(procalcitonin, PCT)(2.74±0.47)ng/ml、C反应蛋白(C-reactive protein, CRP)(17.13±2.58)mg/l、低蛋白血症13例(61.90%)、入院前3个月内使用抗生素9例(42.86%)、抗生素使用时间≥14 d 15例(71.43%)高于对照组入院时血糖(9.01±1.19)mmol/l、血清降钙素原(procalcitonin, PCT)(2.42±0.72)ng/ml、C反应蛋白(C-reactive protein, CRP)(15.62±3.38)mg/l、低蛋白血症5例(13.51%)、入院前3个月使用抗生素4例(10.81%)、抗生素使用≥14 d 6例(16.22%)(P<0.05)。多因素Logistic 回归分析显示,入院时血糖(OR=5.375; P=0.001)、低蛋白血症(OR=10.508; P=0.014)、入院前3个月使用抗生素(OR=13.521; P=0.029)、抗生素使用≥14 d(OR=11.379; P=0.013)为COPD真菌感染的危险因素。建立预测COPD真菌感染风险的列线图模型,校准曲线显示与实际曲线拟合度高。结论 入院时血糖、低白蛋白血症、入院前3个月使用抗生素和/或抗生素使用≥14 d可早期预测COPD合并真菌感染的危险因素。
Abstract:
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备注/Memo

备注/Memo:
通信作者: 王石林, Email: 389225256@qq.com
更新日期/Last Update: 2024-10-25