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[1]张 燕,杨跃青,邱 峥.IgG联合血清细胞因子对肺结核并发慢性肺曲霉菌病的诊断意义[J].中华肺部疾病杂志,2024,(05):809-812.[doi:10.3877/cma.j.issn.1674-6902.2024.05.027]
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IgG联合血清细胞因子对肺结核并发慢性肺曲霉菌病的诊断意义(PDF)

《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2024年05期
页码:
809-812
栏目:
临床研究
出版日期:
2024-10-25

文章信息/Info

Title:
-
作者:
张 燕1; 杨跃青2; 邱 峥1
710100 西安,陕西省结核病防治院中西医结合科1
710003 西安,陕西省中医医院肺结核科2
Author(s):
-
关键词:
肺结核;  慢性肺曲霉菌病;  细胞因子;  IgG
Keywords:
-
分类号:
R562
DOI:
10.3877/cma.j.issn.1674-6902.2024.05.027
摘要:
目的 分析血清细胞因子谱在单纯肺结核(pulmonary tuberculosis, PTB)及PTB并发慢性肺曲霉菌病(chronic pulmonary aspergillosis- tuberculosis, CPA-TB)中的表达及临床意义。方法 选择2019年1月至2023年1月我院收治的59例PTB患者,PTB患者22例为对照组,CPA-TB患者37例为观察组。采用Luminex xMAP技术检测血清细胞因子水平,分析两组临床特征及血清细胞因子诊断CPA-TB的意义。结果 观察组IgG(221.92±286.88)mg/L、中性粒细胞计数(4.27±1.79 )109/L、白细胞计数(6.09±3.52)109/L高于对照组IgG(77.92±68.46)mg/L、中性粒细胞计数(3.08±2.64)109/L、白细胞计数(3.85±4.68)109/L(P<0.05)。观察组干扰素-γ(interferon-γ, IFN-γ)(6.96±12.85 )pg/ml低于对照组INF-γ(14.32±20.66)pg/ml,观察组白细胞介素(interleukin, IL)-1β(37.08±66.75)pg/ml、IL-6(188.97±423.71)pg/ml、IL-8(160.38±315.26)pg/ml、IL-12p70(40.17±32.80 )pg/ml、肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)(93.32±126.15)pg/ml高于对照组IL-1β(10.90±22.86)pg/ml、IL-6(5.13±3.15 )pg/ml、IL-8(13.15±6.85)pg/ml、IL-12p70(18.66±32.04 )pg/ml、TNF-α(35.22±50.79)pg/ml(P<0.05)。IL-1β、IL-6、IL-8诊断CPA-TB受试者工作特征曲线下面积>0.750。IgG联合IL-1β+IL-6+IL-8诊断CPA-TB AUC:0.891(95%CI:0.797～0.952),阳性预测值及阴性预测值佳,分别为81.03%、81.46%。结论 CPA-TB与PTB血清细胞因子水平存在表达差异,IL-1β、IL-6、IL-8可作为潜在标志物用于PTB中CPA的准确诊断,具有临床意义。
Abstract:
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备注/Memo

备注/Memo:
基金项目: 陕西省卫生健康科研基金(2021D027)
作通信作者: 杨跃青,Email: yyq0724@sohu.com
更新日期/Last Update: 2024-10-25