|本期目录/Table of Contents|

[1]陈用来,谌 莉,李 勇,等.放射性肺纤维化的研究近展[J].中华肺部疾病杂志,2024,(06):1042-1047.[doi:10.3877/cma.j.issn.1674-6902.2024.06.038
]
点击复制

放射性肺纤维化的研究近展(PDF)

《中华肺部疾病杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2024年06期
页码:
1042-1047
栏目:
综述
出版日期:
2024-12-25

文章信息/Info

Title:
-
作者:
陈用来; 谌 莉; 李 勇; 傅仕艳; 冉永红; 赵雅贞; 郝玉徽
400038 重庆,陆军军医大学军事预防医学系复合伤研究所创伤与化学中毒全国重点实验室
Author(s):
-
关键词:
放射性肺纤维化;  放射治疗;  分子靶向治疗;  间充质干细胞
Keywords:
-
分类号:
R563
DOI:
10.3877/cma.j.issn.1674-6902.2024.06.038
摘要:
-
Abstract:
-

参考文献/References:

1 Marks LB, Bentzen SM, Deasy JO, et al. Radiation dose-volume effects in the lung[J]. Int J Radiat Oncol Biol Phys, 2010, 76(3 Suppl): S70-S76.
2 Wang P, Yan Z, Zhou PK, et al. The promising therapeutic approaches for radiation-induced pulmonary fibrosis: Targeting radiation-induced mesenchymal transition of alveolar type Ⅱ epithelial cells[J]. Int J Mol Sci, 2022, 23(23): 15014.
3 Hanania AN, Mainwaring W, Ghebre YT, et al. Radiation-induced lung injury: Assessment and management[J]. Chest, 2019, 156(1): 150-162.
4 Kasmann L, Dietrich A, Staab-Weijnitz CA, et al. Radiation-induced lung toxicity-cellular and molecular mechanisms of pathogenesis, management, and literature review[J]. Radiat Oncol, 2020,15(1): 214.
5 Deutsch E, Meziani L. Radiation-induced pulmonary fibrosis: New potential targets[J]. Cancer Radiother, 2023, 27(6-7): 491-493.
6 徐燕梅, 崔天祥, 张晓晶, 等. 外周血单核细胞数量与肺癌放疗近、远期疗效的相关性分析[J/CD]. 中华肺部疾病杂志(电子版), 2014, 7(2): 159-164.
7 Jarzebska N, Karetnikova ES, Markov AG, et al. Scarred lung. An update on radiation-induced pulmonary fibrosis[J]. Front Med(Lausanne), 2020, 7: 585756.
8 Groves AM, Johnston CJ, Williams JP, et al. Role of infiltrating monocytes in the development of radiation-induced pulmonary fibrosis[J]. Radiat Res, 2018, 189(3): 300-311.
9 Paix A, Antoni D, Waissi W, et al. Total body irradiation in allogeneic bone marrow transplantation conditioning regimens: A review[J]. Crit Rev Oncol Hematol, 2018, 123: 138-148.
10 Ding X, Ji W, Li J, et al. Radiation recall pneumonitis induced by chemotherapy after thoracic radiotherapy for lung cancer[J]. Radiat Oncol, 2011, 6: 24.
11 Yamaguchi S, Ohguri T, Matsuki Y, et al. Radiotherapy for thoracic tumors: association between subclinical interstitial lung disease and fatal radiation pneumonitis[J]. Int J Clin Oncol, 2015, 20(1): 45-52.
12 Ahmadi MM, Rezaee R, Rezaianzadeh A, et al. Developing a model for hospitals' emergency department preparedness in radiation and nuclear incidents and nuclear terrorism in Iran[J]. Bull Emerg Trauma, 2019, 7(3): 300-306.
13 Kim H, Park SH, Han SY, et al. LXA(4)-FPR2 signaling regulates radiation-induced pulmonary fibrosis via crosstalk with TGF-beta/Smad signaling[J]. Cell Death Dis, 2020, 11(8): 653.
14 Chen Z, Wu Z, Ning W. Advances in molecular mechanisms and treatment of radiation-induced pulmonary fibrosis[J]. Transl Oncol, 2019, 12(1): 162-169.
15 Park HR, Jo SK, Jung U. Ionizing radiation promotes epithelial-to-mesenchymal transition in lung epithelial cells by TGF-beta-producing M2 macrophages[J]. In Vivo, 2019, 33(6): 1773-1784.
16 Son B, Kwon T, Lee S, et al. CYP2E1 regulates the development of radiation-induced pulmonary fibrosis via ER stress-and ROS-dependent mechanisms[J]. Am J Physiol Lung Cell Mol Physiol, 2017, 313(5): L916-L929.
17 Sunil GSN, Raghavi R, Devipriya N, et al. Radiation-induced lung injury: impact on macrophage dysregulation and lipid alteration-a review[J]. Immunopharmacol Immunotoxicol, 2019, 41(3): 370-379.
18 Han G, Zhang H, Xie CH, et al. Th2-like immune response in radiation-induced lung fibrosis[J]. Oncol Rep, 2011, 26(2): 383-388.
19 Yuan M, Zhao M, Sun X, et al. The mapping of mRNA alterations elucidates the etiology of radiation-induced pulmonary fibrosis[J]. Front Genet, 2022, 13: 999127.
20 Li M, Liu P, Ke Y, et al. Research progress on macrophage in radiation induced lung injury[J]. J Zhejiang University(Medical Sciences), 2020, 49(5): 623-628.
21 Wang D, Li Z, Zhang Y, et al. Bibliometric analysis of research relating to radiation-induced lung injury[2001-2020][J]. Ann Palliat Med, 2021, 10(10): 11166-11176.
22 Wang Z, Chen J, Su L, et al. Downregulation of miR-761 ameliorates radiation-induced pulmonary fibrosis by regulating PGC-1alpha[J]. Exp Lung Res, 2022, 48(4-6): 158-167.
23 Kim JS, Son Y, Jung MG, et al. Geranylgeranylacetone alleviates radiation-induced lung injury by inhibiting epithelial-to-mesenchymal transition signaling[J]. Mol Med Rep, 2016, 13(6): 4666-4670.
24 Weytjens R, Erven K, De RD. Radiation pneumonitis: occurrence, prediction, prevention and treatment[J]. Belg J Med Oncol, 2013, 7(4): 105-110.
25 Williams JP, Johnston CJ, Finkelstein JN. Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction?[J]. Curr Drug Targets, 2010, 11(11): 1386-1394.
26 Qin W, Liu B, Yi M, et al. Antifibrotic agent pirfenidone protects against development of radiation-induced pulmonary fibrosis in a murine model[J]. Radiat Res, 2018, 190(4): 396-403.
27 UpToDate.(2024). Clinical manifestations, prevention, and treatment of radiation-induced fibrosis. Retrieved October 17, 2024, from https://www.uptodate.com/contents/clinical-manifestations-prevention-and-treatment-of-radiation-induced-fibrosis.
28 应航洁, 陈亚梅, 陈梦圆, 等. 放射性肺损伤发生机制研究进展[J]. 中华放射肿瘤学杂志, 2021, 30(2): 213-216.
29 敖兴坤, 严紫艳, 顾永清. 上皮间质转化在放射性肺纤维化中的作用及治疗策略[J]. 中华放射医学与防护杂志, 2023, 43(4): 307-313.
30 Chen ZJ, Wu ZQ, Wen N. Advances in molecular mechanisms and treatment of radiation-induced pulmonary fibrosis[J]. Translational Oncology, 2019, 12(1): 162-169.
31 中国医疗保健国际交流促进会胸部肿瘤分会, 中国肿瘤放射治疗联盟. 放射相关性肺炎中国专家诊治共识[J]. 中华肿瘤防治杂志, 2022, 29(14): 1015-1022.
32 Fernando LM, Adeel S, Basar M A, et al. In-gel SOD assay reveals SOD-2 is the single active, water-soluble SOD enzyme in C. elegans[J]. Free Radic Res, 2021, 55(6): 619-624.
33 Liu J, Wang X, Wang F, et al. Attenuation effects of heparin-superoxide dismutase conjugate on bleomycin-induced lung fibrosis in vivo and radiation-induced inflammatory cytokine expression in vitro[J]. Biomed Pharmacother, 2009, 63(7): 484-491.
34 Yu Z, Xu C, Song B, et al. Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances[J]. J Transl Med, 2023, 21(1): 708.
35 Pan J, He H, Su Y, et al. In Vivo Radioprotective Activity of Cell-Permeable Bifunctional Antioxidant Enzyme GST-TAT-SOD against Whole-Body Ionizing Irradiation in Mice[J]. Oxid Med Cell Longev, 2017, 2017: 2689051.
36 Ruan Z, Liu Y, Chang G, et al. Molecular characterization of two CuZn-SOD family proteins in the Pacific oyster Crassostrea gigas[J]. Comp Biochem Physiol B Biochem Mol Biol, 2022, 260: 110736.
37 Chen D, Ai X, Li Y, et al. Protective effects of Cu/Zn-SOD and Mn-SOD on UVC radiation-induced damage in NIH/3T3 cells and murine skin[J]. Acta Histochem, 2023, 125(4): 152030.
38 Liu T, Yang Q, Zheng H, et al. Multifaceted roles of a bioengineered nanoreactor in repressing radiation-induced lung injury[J]. Biomaterials, 2021, 277: 121103.
39 Tahamtan R, Shabestani MA, Tahamtani Y, et al. Radioprotective effect of melatonin on radiation-induced lung injury and lipid peroxidation in rats[J]. Cell J, 2015, 17(1): 111-120.
40 Yahyapour R, Amini P, Saffar H, et al. Protective effect of metformin, resveratrol and alpha-lipoic acid on radiation- induced pneumonitis and fibrosis: A histopathological study[J]. Curr Drug Res Rev, 2019, 11(2): 111-117.
41 Seyedpour N, Motevaseli E, Taeb S, et al. Protective effects of alpha-lipoic acid, resveratrol, and apigenin against oxidative damages, histopathological changes, and mortality induced by lung irradiation in rats[J]. Curr Radiopharm, 2023, 17(1): 99-110.
42 Azmoonfar R, Amini P, Yahyapour R, et al. Mitigation of radiation-induced pneumonitis and lung fibrosis using alpha-lipoic acid and resveratrol[J]. Antiinflamm Antiallergy Agents Med Chem, 2020, 19(2): 149-157.
43 Magnusson M, Hoglund P, Johansson K, et al. Pentoxifylline and vitamin E treatment for prevention of radiation-induced side-effects in women with breast cancer: a phase two, double-blind, placebo-controlled randomised clinical trial(Ptx-5)[J]. Eur J Cancer, 2009, 45(14): 2488-2495.
44 Lee JG, Shim S, Kim MJ, et al. Pentoxifylline regulates plasminogen activator inhibitor-1 expression and protein kinase a phosphorylation in radiation-induced lung fibrosis[J]. Biomed Res Int, 2017, 2017: 1279280.
45 Delanian S, Balla-Mekias S, Lefaix JL. Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol[J]. J Clin Oncol, 1999, 17(10): 3283-3290.
46 Chen C, Yang S, Zhang M, et al. Triptolide mitigates radiation-induced pulmonary fibrosis via inhibition of axis of alveolar macrophages-NOXes-ROS-myofibroblasts[J]. Cancer Biol Ther, 2016, 17(4): 381-389.
47 Guo K, Chen J, Chen Z, et al. Triptolide alleviates radiation-induced pulmonary fibrosis via inhibiting IKKbeta stimulated LOX production[J]. Biochem Biophys Res Commun, 2020, 527(1): 283-288.
48 Park JH, Ryu SH, Choi EK, et al. SKI2162, an inhibitor of the TGF-beta type I receptor(ALK5), inhibits radiation-induced fibrosis in mice[J]. Oncotarget, 2015, 6(6): 4171-4179.
49 Park J, Choi J, Cho I, et al. Radiotherapy-induced oxidative stress and fibrosis in breast cancer are suppressed by vactosertib, a novel, orally bioavailable TGF-beta/ALK5 inhibitor[J]. Sci Rep, 2022, 12(1): 16104.
50 Dadrich M, Nicolay NH, Flechsig P, et al. Combined inhibition of TGFbeta and PDGF signaling attenuates radiation-induced pulmonary fibrosis[J]. Oncoimmunology, 2016, 5(5): e1123366.
51 Anscher MS, Thrasher B, Zgonjanin L, et al. Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury[J]. Int J Radiat Oncol Biol Phys, 2008, 71(3): 829-837.
52 Li M, Ping G, Plathow C, et al. Small molecule receptor tyrosine kinase inhibitor of platelet-derived growth factor signaling(SU9518)modifies radiation response in fibroblasts and endothelial cells[J]. BMC Cancer, 2006, 6: 79.
53 Abdollahi A, Li M, Ping G, et al. Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis[J]. J Exp Med, 2005, 201(6): 925-935.
54 Dadrich M, Nicolay NH, Flechsig P, et al. Combined inhibition of TGFbeta and PDGF signaling attenuates radiation-induced pulmonary fibrosis[J]. Oncoimmunology, 2016, 5(5): e1123366.
55 Sternlicht MD, Wirkner U, Bickelhaupt S, et al. Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab[J]. Respir Res, 2018, 19(1): 14.
56 Bickelhaupt S, Erbel C, Timke C, et al. Effects of CTGF blockade on attenuation and reversal of radiation-induced pulmonary fibrosis[J]. J Natl Cancer Inst, 2017,109(8).doi: 10.1093/jnci/djw339.
57 Li Q, Cheng Y, Zhang Z, et al. Inhibition of ROCK ameliorates pulmonary fibrosis by suppressing M2 macrophage polarisation through phosphorylation of STAT3[J]. Clin Transl Med, 2022, 12(10): e1036.
58 Ostrau C, Hulsenbeck J, Herzog M, et al. Lovastatin attenuates ionizing radiation-induced normal tissue damage in vivo[J]. Radiother Oncol, 2009, 92(3): 492-499.
59 Dong LH, Jiang YY, Liu YJ, et al. The anti-fibrotic effects of mesenchymal stem cells on irradiated lungs via stimulating endogenous secretion of HGF and PGE2[J]. Sci Rep, 2015, 5: 8713.
60 Agha Elie EI, Kramann R, Schneider RK, et al. Mesenchymal stem cells in fibrotic disease[J]. Cell Stem Cell, 2017, 21(2): 166-177.
61 Rong X, Liu J, Yao X, et al. Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt/beta-catenin pathway[J]. Stem Cell Res Ther, 2019, 10(1): 98.
62 Zhang Y, Jiang X, Ren L. Optimization of the adipose-derived mesenchymal stem cell delivery time for radiation-induced lung fibrosis treatment in rats[J]. Sci Rep, 2019, 9(1): 5589.
63 Guo Z, Zhang Y, Yan F. Potential of mesenchymal stem cell-based therapies for pulmonary fibrosis[J]. DNA Cell Biol, 2022, 41(11): 951-965.
64 Molteni A, Wolfe LF, Ward WF, et al. Effect of an angiotensin Ⅱ receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta(TGF-beta)and alpha-actomyosin(alpha SMA), important mediators of radiation-induced pneumopathy and lung fibrosis[J]. Curr Pharm Des, 2007, 13(13): 1307-1316.
65 Hedayatyanfard K, Ziai SA, Niazi F, et al. Losartan ointment relieves hypertrophic scars and keloid: A pilot study[J]. Wound Repair Regen, 2018, 26(4): 340-343.
66 Couluris M, Kinder BW, Xu P, et al. Treatment of idiopathic pulmonary fibrosis with losartan: a pilot project[J]. Lung, 2012, 190(5): 523-527.
67 Gao F, Fish BL, Moulder JE, et al. Enalapril mitigates radiation-induced pneumonitis and pulmonary fibrosis if started 35 days after whole-thorax irradiation[J]. Radiat Res, 2013, 180(5): 546-552.
68 Mahmood J, Jelveh S, Zaidi A, et al. Targeting the Renin-angiotensin system combined with an antioxidant is highly effective in mitigating radiation-induced lung damage[J]. Int J Radiat Oncol Biol Phys, 2014, 89(4): 722-728.
69 Flechsig P, Dadrich M, Bickelhaupt S, et al. LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-beta and BMP-associated proinflammatory and proangiogenic signals[J]. Clin Cancer Res, 2012, 18(13): 3616-3627.
70 Rangarajan S, Locy ML, Luckhardt TR, et al. Targeted therapy for idiopathic pulmonary fibrosis: Where to now?[J]. Drugs, 2016, 76(3): 291-300.
71 Qin W, Liu B, Yi M, et al. Antifibrotic agent pirfenidone protects against development of radiation-induced pulmonary fibrosis in a murine model[J]. Radiat Res, 2018, 190(4): 396-403.
72 Simone NL, Soule BP, Gerber L, et al. Oral pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study[J]. Radiat Oncol, 2007, 2: 19.
73 Takahashi S, Endo M, Fukuda Y, et al. Nintedanib-induced delayed mucosal healing after adjuvant radiation in a case of oropharyngeal carcinoma[J]. Case Rep Oncol, 2022, 15(2): 776-782.
74 邹 晶, 徐兴祥, 王大新, 等. 肺癌放化疗“实时”疗效评估方法的研究进展[J/CD]. 中华肺部疾病杂志(电子版), 2013, 6(4): 360-363.

备注/Memo

备注/Memo:
基金项目: 重庆市教委科学技术研究计划重点项目(KJZD-K202312801)
通信作者: 郝玉徽, Email: yuhuihao@tmmu.edu.cn
更新日期/Last Update: 2024-12-25